Comprehensive identification of immune-associated biomarkers based on network and mRNA expression patterns in membranous glomerulonephritis.

ABSTRACT:

Background

Membranous glomerulonephritis (MGN) is the most common cause of nephrotic syndrome in adult patients. Despite extensive evidences suggested that many immune-related genes could serve as effective biomarkers in MGN, the potential has not been sufficiently understood because of most previous studies have concentrated on individual gene and not the entire interaction network.

Methods

Here, we integrated multiple levels of data containing immune-related genes, MGN-related genes, protein-protein interaction (PPI) networks and gene expression profiling data to construct an immune or MGN-directed neighbor network (IOMDN network) and an MGN-related genes-directed network (MGND network).

Results

Our analysis suggested that immune-related genes in the PPI network hav

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6056925 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature