Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.

ABSTRACT:

Background

The role of the innate immune system in Alzheimer's disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive deficits or AD-related neuropathology. We investigated whether genetic risk scores for seven immune diseases and central nervous system traits were related to cognitive decline (n_max = 1601), classical AD neuropathology (n_max = 985), or microglial density (n_max = 184).

Methods

Longitudinal cognitive decline, postmortem amyloid and tau neuropathology, microglial density, and gene module expression from bulk brain tissue were all measured in participants from

SUBMITTER: Felsky D 

PROVIDER: S-EPMC6057096 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature