Middle ear irrigation using a hydrodebrider decreases biofilm surface area in an animal model of otitis media.

ABSTRACT:

Objective

To compare the safety and efficacy of manual and powered irrigation of the middle ear using saline or 1% baby shampoo to treat biofilm-forming bacterial middle ear infections.

Background

Biofilms play a major role in recalcitrant otitis media and are challenging to treat. Many therapeutic strategies have been attempted and the role of topical therapies is still being investigated. Topical irrigation using saline or 1% baby shampoo and the use of a hydrodebrider have been investigated in biofilms involved in chronic rhinosinusitis and their role within the middle ear is yet to be determined.

Methods

Twenty-two adult chinchillas underwent bilateral trans-bullar inoculation of non-typable biofilm forming Haemophilus influenza followed by unilateral middl

SUBMITTER: Abi Hachem R 

PROVIDER: S-EPMC6057225 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature