Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever?

ABSTRACT: Potential use of total nitrite plus nitrate (NOx) and nitrite (NO₂^-) separately as surrogate markers for serum nitric oxide in severe dengue and their longitudinal changes along with the progression of infection was studied. Deproteinized sera from confirmed dengue fever (DF, n = 145) and dengue hemorrhagic fever (DHF, n = 74) patients on admission-A, critical-C, discharge-D, and convalescence-CON stages and from age-gender matched healthy individuals (HC, n = 77) were taken to assess NO₂^- and NOx levels using Griess and modified Griess assays. Serum NOx in DHFA was significantly lower compared to DFA (p < 0.001). HC had the lowest NOx and NO₂^- compared to all patient categories (p < 0.001)

SUBMITTER: Mapalagamage M 

PROVIDER: S-EPMC6057279 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature