Ontology highlight
ABSTRACT:
SUBMITTER: Miyamoto K
PROVIDER: S-EPMC6057489 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cell reports 20180701 2
Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells affects this transcriptional reprogramming. Here, we investigated the relationship between the chromatin opening and transcriptional activation. We reveal changes in chromatin accessibility and their relevance to transcriptional reprogramming after transplantation of somatic nuclei into Xenopus oocytes. Genes that are silenced, but have pre-exi ...[more]