Progression marker of Parkinson's disease: a 4-year multi-site imaging study.

ABSTRACT: Progression markers of Parkinson's disease are crucial for successful therapeutic development. Recently, a diffusion magnetic resonance imaging analysis technique using a bitensor model was introduced allowing the estimation of the fractional volume of free water within a voxel, which is expected to increase in neurodegenerative disorders such as Parkinson's disease. Prior work demonstrated that free water in the posterior substantia nigra was elevated in Parkinson's disease compared to controls across single- and multi-site cohorts, and increased over 1 year in Parkinson's disease but not in controls at a single site. Here, the goal was to validate free water in the posterior substantia nigra as a progression marker in Parkinson's disease, and describe the pattern of progression of free w

SUBMITTER: Burciu RG 

PROVIDER: S-EPMC6057495 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature