Surface Modification of Cisplatin-Complexed Gold Nanoparticles and Its Influence on Colloidal Stability, Drug Loading, and Drug Release.

ABSTRACT: Cisplatin-complexed gold nanoparticles (Pt^II-AuNP) provide a promising strategy for chemo-radiation-based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis and its influence on drug payload, stability, and release. In this paper, poly(ethylene glycol) (PEG)-stabilized Pt^II-AuNP was synthesized as a model antitumor drug platform, where Pt^II is attached via a carboxyl-terminated dendron ligand. Surface modification by PEG and its influence on drug loading, colloidal stability, and drug release were assessed. Complexation with Pt^II significantly degrades colloidal stability of the conjugate; however, PEGylation provides substantial improvement of stability in conjunct

SUBMITTER: Tan J 

PROVIDER: S-EPMC6057618 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature