Urinary Biomarkers of Kidney Tubular Damage and Risk of Cardiovascular Disease and Mortality in Elders.

ABSTRACT:

Rationale & objective

Novel urinary biomarkers have enabled earlier detection of kidney tubular damage, but their prognostic value for adverse cardiovascular outcomes is uncertain. We hypothesized that tubular damage, measured by urine α₁-microglobulin (A1M), amino-terminal propeptide of type III procollagen (PIIINP), and neutrophil gelatinase-associated lipocalin (NGAL), would be associated with higher risks for cardiovascular events and mortality among elders.

Study design

Case-cohort study.

Setting & participants

This study included a randomly selected subcohort (n=502), cardiovascular disease (CVD) cases (n=245), and heart failure cases (n=220) from the Health, Aging, and Body Composition (Health ABC) Study.

Predictors

Baseline urine A1M, PIIINP,

SUBMITTER: Jotwani V 

PROVIDER: S-EPMC6057830 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature