Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.

ABSTRACT:

Background and purpose

Antioxidants provide a promising therapeutic effect for the cardiovascular disease. Luteolin, a polyphenolic bioflavonoid, is known to confer cardioprotection, although the underlying mechanisms, especially the role of luteolin on the antioxidant enzymes, such as the peroxiredoxin family, remain unknown.

Experimental approach

We measured the effects of luteolin on myocardial ischaemia/reperfusion (MI/R) injury in vivo (Sprague-Dawley rats) and in vitro, together with the underlying mechanisms, with a focus on signalling by peroxiredoxins. H9c2 cells were used to assess the changes in peroxiredoxins and the other antioxidant enzymes. Oxidative stress, cardiac function, LDH release, ROS and infarct size were also assayed.

Key results

Luteolin exer

SUBMITTER: Wei B 

PROVIDER: S-EPMC6057904 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature