Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis.

ABSTRACT: Although the inflammatory and proliferative phases of wound healing have been well described, much less is known about how healing resolves. During the resolution phase, pruning of the capillary bed and maturation of capillaries occurs and influences the final strength and fidelity of the wound. PEDF, an endogenous anti-angiogenic factor, is produced in wounds and may contribute to the removal of capillaries during wound resolution. This study utilized PEDF^-/- mice to examine how PEDF influences wound angiogenesis, particularly capillary density and permeability. The absence of PEDF led to transient changes in dermal wound closure and collagen content, but caused substantial changes in wound angiogenesis. Compared to wild type (WT) mice, wounds from PEDF^-/- mice exhib

SUBMITTER: Michalczyk ER 

PROVIDER: S-EPMC6057962 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature