The effects of the elastin polymorphisms on carotid intima-media thickness in women aged 30 - 70.

ABSTRACT:

Purpose

Elastin is one of the major determinants of arterial distensibility of large blood vessels that forms the principal component of elastic fibers from the media of arteries. However, the association between elastin(ELN) genotype and vascular function is still unclear.

Methods

120women were recruited from the Saha-gu (Busan, Korea) Community Center. Measurements of body composition and vascular function included carotid intima-media thickness (CIMT), carotid artery luminal diameter (CLD), minimum (diastolic) artery luminal diameter (CLDmin) and maximum (systolic) artery luminal diameter (CLDmax). Genotyping for the ELN (rs 2071307) polymorphism was performed using the TaqMan approach. ELN gene distribution of subjects were in the Hardy-Weinberg equilibrium (p=0.402).

SUBMITTER: Lim ST 

PROVIDER: S-EPMC6058069 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature