Prevalence and Genotyping of Torque Teno Virus in HBV/HIV and Chronic HBV Patients in Iran

ABSTRACT: Background:Torque teno virus (TTV) was the first human Anelloviridae detected in a Japanese patient with an unknown type of hepatitis in 1997. TTV is by far the first known single-stranded circular DNA virus infecting human. In spite of its widespread nature in human population, its pathogenesis is still unclear. In addition, information regarding TTV infection in Iranian population is limited. Therefore, we attempted to determine the prevalence and genotype of TTV in three groups: HIV/HBV patients, chronic hepatitis B patients, and healthy individuals. Methods:The presence of TTV DNA in sera was investigated using PCR. The primer sets encompassing two 5΄-UTR and N22 regions were used, and the positive products were collected for sequencing. Phylogenetic tree was generated based on N22 reg

SUBMITTER: Najafimemar Z 

PROVIDER: S-EPMC6058187 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature