Statin use and risk of recurrent venous thrombosis: results from the MEGA follow-up study.

ABSTRACT:

Introduction

Whether statin use after first venous thrombosis reduces the risk of recurrence is uncertain. Therefore, we aimed to examine the risk of recurrent venous thrombosis in statin users vs non-users.

Methods

Patients with a first venous thrombosis were recruited from the MEGA follow-up study. Information on statin use was obtained by linkage to the Dutch Foundation for Pharmaceutical Statistics register. Linkage was successful in 54% of all patients (n = 2,547). Cox-regression models with statin-exposure as a time-dependent co-variate were used to estimate hazard ratios (HR) with 95% confidence intervals (CI 95) for recurrence.

Results

Statin therapy was continued in 153 (6.0%) patients and initiated in 233 (9.1%) patients during a median follow-up of 5.7 year

SUBMITTER: Brækkan SK 

PROVIDER: S-EPMC6058203 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature