Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial.

ABSTRACT: Transfusing platelets during massive hemorrhage is debated because of a lack of high-quality evidence concerning outcomes in trauma patients. The objective of this study was to examine the effect of platelet transfusions on mortality in severely injured trauma patients. This work analyzed PROPPR (Pragmatic, Randomized Optimal Platelet and Plasma Ratios) trial patients who received only the first cooler of blood products, which either did or did not contain platelets. Primary outcomes were all-cause mortality at 24 hours and 30 days and hemostasis. Secondary outcomes included cause of death, complications, and hospital-, intensive care unit (ICU)-, and ventilator-free days. Continuous variables were compared using Wilcoxon rank sum tests. Categorical variables were compared using Fisher's e

SUBMITTER: Cardenas JC 

PROVIDER: S-EPMC6058234 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature