Pathogenesis, prevention, and management of bleeding and thrombosis in patients with liver diseases.

ABSTRACT: Patients with liver diseases may develop alterations in all components of the hemostatic system. Thrombocytopenia, low levels of coagulation factors and inhibitors, low levels of fibrinolytic proteins, and increased levels of endothelial-derived proteins such as von Willebrand factor are all part of the coagulopathy of liver disease. Due to concomitant changes in pro- and antihemostatic drivers, the net effects of these complex hemostatic changes have long been unclear. According to current concepts, the hemostatic system of patients with liver disease is in an unstable balance, which explains the occurrence of both bleeding and thrombotic complications. This review will discuss etiology and management of bleeding and thrombosis in liver disease and will outline unsolved clinical questions

SUBMITTER: Lisman T 

PROVIDER: S-EPMC6058283 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature