The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities.

ABSTRACT: Motility is an important virulence trait for many bacterial pathogens, allowing them to position themselves in appropriate locations at appropriate times. The motility structures type IV pili and flagella are also involved in sensing surface contact, which modulates pathogenicity. In Pseudomonas aeruginosa, the PilS-PilR two-component system (TCS) regulates expression of the type IV pilus (T4P) major subunit PilA, while biosynthesis of the single polar flagellum is regulated by a hierarchical system that includes the FleSR TCS. Previous studies of Geobacter sulfurreducens and Dichelobacter nodosus implicated PilR in regulation of non-T4P-related genes, including some involved in flagellar biosynthesis. Here we used transcriptome sequencing (RNA-seq) analysis to identif

SUBMITTER: Kilmury SLN 

PROVIDER: S-EPMC6058289 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature