Leveraging Phylogenetics to Understand HIV Transmission and Partner Notification Networks.

ABSTRACT:

Background

Partner notification is an important component of public health test and treat interventions. To enhance this essential function, we assessed the potential for molecular methods to supplement routine partner notification and corroborate HIV networks.

Methods

All persons diagnosed with HIV infection in Wake County, NC, during 2012-2013 and their disclosed sexual partners were included in a sexual network. A data set containing HIV-1 pol sequences collected in NC during 1997-2014 from 15,246 persons was matched to HIV-positive persons in the network and used to identify putative transmission clusters. Both networks were compared.

Results

The partner notification network comprised 280 index cases and 383 sexual partners and high-risk social contacts (n = 131 H

SUBMITTER: Pasquale DK 

PROVIDER: S-EPMC6058319 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature