Metabolic engineering of Escherichia coli for production of mixed isoprenoid alcohols and their derivatives.

ABSTRACT:

Background

Current petroleum-derived fuels such as gasoline (C₅-C₁₂) and diesel (C₁₅-C₂₂) are complex mixtures of hydrocarbons with different chain lengths and chemical structures. Isoprenoids are hydrocarbon-based compounds with different carbon chain lengths and diverse chemical structures, similar to petroleum. Thus, isoprenoid alcohols such as isopentenol (C₅), geraniol (C₁₀), and farnesol (C₁₅) have been considered to be ideal biofuel candidates. NudB, a native phosphatase of Escherichia coli, is reported to dephosphorylate isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into isopentenol. However, no attention has been paid to its promiscuous activity toward longer chain len

SUBMITTER: Zada B 

PROVIDER: S-EPMC6058358 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature