What does it mean if a patient is positive for anti-Jo-1 in routine hospital practice? A retrospective nested case-control study.

ABSTRACT: Background:  It is widely believed that patients bearing auto-antibodies to histidyl tRNA synthetase (anti-Jo-1) very likely have a connective tissue disease including myositis and interstitial lung disease.  The value of positive tests in low disease prevalence settings such as those tested in routine care is unknown.  We sought to determine the value of anti-Jo-1 auto-antibodies in routine practice. Methods: Our study was a nested case control study within a retrospective cohort of all patients tested for anti-ENA our hospital, from any hospital department, between January 2013 and December 2014.  Data was extracted from electronic records of anti-Jo-1 positive patients and randomly selected ENA negative patients (ratio of 1:2), allowing for a minimum follow up of at least

SUBMITTER: Jobanputra P 

PROVIDER: S-EPMC6058461 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature