Direct Observation of Oxygen Rebound with an Iron-Hydroxide Complex.

ABSTRACT: The rebound mechanism for alkane hydroxylation was invoked over 40 years ago to help explain reactivity patterns in cytochrome P450, and subsequently has been used to provide insight into a range of biological and synthetic systems. Efforts to model the rebound reaction in a synthetic system have been unsuccessful, in part because of the challenge in preparing a suitable metal-hydroxide complex at the correct oxidation level. Herein we report the synthesis of such a complex. The reaction of this species with a series of substituted radicals allows for the direct interrogation of the rebound process, providing insight into this uniformly invoked, but previously unobserved process.

SUBMITTER: Zaragoza JPT 

PROVIDER: S-EPMC6058725 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature