Related Endogenous Retrovirus-K Elements Harbor Distinct Protease Active Site Motifs.

ABSTRACT: Background: Endogenous retrovirus-K is a group of related genomic elements descending from retroviral infections in human ancestors. HML2 is the clade of these viruses which contains the most intact provirus copies. These elements can be transcribed and translated in healthy and diseased tissues, and some of them produce active retroviral enzymes, such as protease. Retroviral gene products, including protease, contribute to illness in exogenous retroviral infections. There are ongoing efforts to test anti-retroviral regimens against endogenous retroviruses. Herein, we examine the potential activity and diversity of human endogenous retrovirus-K proteases, and their potential for impact on immunity and human disease. Results: Sequences similar to the endogenous retrovirus-K HM

SUBMITTER: Turnbull MG 

PROVIDER: S-EPMC6058741 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature