Leukemia reconstitution in vivo is driven by cells in early cell cycle and low metabolic state.

ABSTRACT: In contrast to well-established hierarchical concepts of tumor stem cells, leukemia-initiating cells in B-cell precursor acute lymphoblastic leukemia have not yet been phenotypically identified. Different subpopulations, as defined by surface markers, have shown equal abilities to reconstitute leukemia upon transplantation into immunodeficient mice. Using a non-obese diabetes/severe combined immunodeficiency human acute lymphoblastic leukemia mouse model and cell cycle analysis annotating cells to distinct cycle phases, we functionally characterized leukemia-initiating cells and found that cells in all stages of the cell cycle are able to reconstitute leukemia in vivo, with early cycling cells (G1b^low population) exhibiting the highest leukemia-initiating potential. Inter

SUBMITTER: Trentin L 

PROVIDER: S-EPMC6058781 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature