Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A.
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ABSTRACT:
SUBMITTER: Nordlohne J
PROVIDER: S-EPMC6058956 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
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Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A.
Nordlohne Johannes J Helmke Alexandra A Ge Shuwang S Rong Song S Chen Rongjun R Waisman Ari A Haller Hermann H von Vietinghoff Sibylle S
JACC. Basic to translational science 20180110 1
Effective therapy of atherosclerotic complications in patients with chronic kidney disease (CKD) is an unmet clinical need. Cardiovascular events are the most common cause of death. At a glomerular filtration rate ≤60 ml/min, these events are increased also after correction for common risk factors. Previous studies have reported enhanced vascular inflammation in mice and recently also in humans. Our current data show, in a mouse model of atherosclerosis in moderate renal impairment, that interle ...[more]
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