Shape and diffusion tensor imaging based integrative analysis of the hippocampus and the amygdala in Alzheimer's disease.

ABSTRACT: We analyzed, in an integrative fashion, the morphometry and structural integrity of the bilateral hippocampi and amygdalas in Alzheimer's disease (AD) using T1-weighted images and diffusion tensor images (DTIs). We detected significant hippocampal and amygdalar volumetric atrophies in AD relative to healthy controls (HCs). Shape analysis revealed significant region-specific atrophies with the hippocampal atrophy mainly being concentrated on the CA1 and CA2 while the amygdalar atrophy was concentrated on the basolateral and basomedial. In all structures, the structural integrity displayed a significantly decreased mean fractional anisotropy (FA) value and an increased mean trace value in AD. In addition to the inter-group comparisons, we systematically evaluated the discriminative power of

SUBMITTER: Tang X 

PROVIDER: S-EPMC6058972 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature