Longitudinal analysis of impulse control disorders in Parkinson disease.

ABSTRACT:

Objective

To investigate the longitudinal dose-effect relationship between dopamine replacement therapy and impulse control disorders (ICDs) in Parkinson disease (PD).

Methods

We used data from a multicenter longitudinal cohort of consecutive patients with PD with ≤5 years' disease duration at baseline followed up annually up to 5 years. ICDs were evaluated during face-to-face semistructured interviews with movement disorder specialists. Generalized estimating equations and Poisson models with robust variance were used to study the association between several time-dependent definitions of dopamine agonist (DA) use, taking dose and duration of treatment into account, and ICDs at each visit. Other antiparkinsonian drugs were also examined.

Results

Among 411 patients (40

SUBMITTER: Corvol JC 

PROVIDER: S-EPMC6059034 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature