Functional specialization of areas along the anterior-posterior axis of the primate prefrontal cortex.

ABSTRACT: Functional specialization of areas along the anterior-posterior axis of the lateral prefrontal cortex has been speculated but little evidence exists about distinct neurophysiological properties between prefrontal sub-regions. To address this issue we divided the lateral prefrontal cortex into a posterior-dorsal, a mid-dorsal, an anterior-dorsal, a posterior-ventral, and an anterior ventral region. Selectivity for spatial locations, shapes, and colors was evaluated in six monkeys never trained in working memory tasks, while they viewed the stimuli passively. Recordings from over two thousand neurons revealed systematic differences between anterior and posterior regions. In the dorsal prefrontal cortex, anterior regions exhibited the largest receptive fields, longest response latencies, and

SUBMITTER: Riley MR 

PROVIDER: S-EPMC6059101 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature