The Rich-Club Organization in Rat Functional Brain Network to Balance Between Communication Cost and Efficiency.

ABSTRACT: Network analyses of structural connectivity in the brain have highlighted a set of highly connected hubs that are densely interconnected, forming a "rich-club" substrate in diverse species. Here, we demonstrate the existence of rich-club organization in functional brain networks of rats. Densely interconnected rich-club regions are found to be distributed in multiple brain modules, with the majority located within the putative default mode network. Rich-club members exhibit high wiring cost (as measured by connection distance) and high metabolic running cost (as surrogated by cerebral blood flow), which may have evolved to achieve high network communications to support efficient brain functions. Furthermore, by adopting a forepaw electrical stimulation paradigm, we find that the rich-club

SUBMITTER: Liang X 

PROVIDER: S-EPMC6059143 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature