A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer.

ABSTRACT:

Background

Blood-based biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are urgently needed. Current biomarkers lack high sensitivity and specificity for population screening. The gold-standard biomarker, CA 19-9, also fails to demonstrate the predictive value necessary for early detection.

Methods

To validate a functional genomics-based plasma migration signature biomarker panel, plasma tissue factor pathway inhibitor (TFPI), tenascin C (TNC-FN III-C), and CA 19-9 levels were measured by enzyme-linked immunosorbent assays in three early-stage PDAC plasma cohorts, including two independent blinded validation cohorts containing a total of 43 stage I, 163 stage II, 86 chronic pancreatitis, 31 acute biliary obstruction, and 108 controls. Logistic regres

SUBMITTER: Balasenthil S 

PROVIDER: S-EPMC6059209 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature