Trial-by-Trial Hippocampal Encoding Activation Predicts the Fidelity of Cortical Reinstatement During Subsequent Retrieval.

ABSTRACT: According to current models of episodic memory, the hippocampus binds together the neural representation of an experience during encoding such that it can be reinstated in cortex during subsequent retrieval. However, direct evidence linking hippocampal engagement during encoding with subsequent cortical reinstatement during retrieval is lacking. In this study, we aim to directly test the relationship between hippocampal activation during encoding and cortical reinstatement during retrieval. During a scanned encoding session, human participants studied Noun-Sound and Noun-Picture pairs. One day later, during a scanned retrieval session, participants retrieved the sounds and pictures when given the nouns as cues. First, we found that trial-by-trial hippocampal encoding activation was related

SUBMITTER: Danker JF 

PROVIDER: S-EPMC6059210 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature