Reconfiguration of Intrinsic Functional Coupling Patterns Following Circumscribed Network Lesions.

ABSTRACT: Communication between cortical regions is necessary for optimal cognitive processing. Functional relationships between cortical regions can be inferred through measurements of temporal synchrony in spontaneous activity patterns. These relationships can be further elaborated by surveying effects of cortical lesions upon inter-regional connectivity. Lesions to cortical hubs and heteromodal association regions are expected to induce distributed connectivity changes and higher-order cognitive deficits, yet their functional consequences remain relatively unexplored. Here, we used resting-state fMRI to investigate intrinsic functional connectivity (FC) and graph theoretical metrics in 12 patients with circumscribed lesions of the medial prefrontal cortex (mPFC) portion of the Default Network (DN

SUBMITTER: Eldaief MC 

PROVIDER: S-EPMC6059247 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature