Are low levels of serum bicarbonate associated with risk of progressing to impaired fasting glucose/diabetes? A single-centre prospective cohort study in Beijing, China.

ABSTRACT:

Aims

Bicarbonate is involved in many human essential metabolic processes, but little is known about the association between serum bicarbonate and glucose metabolism. This study aims to investigate the association between serum bicarbonate and the risk of progressing to impaired fasting glucose (IFG)/diabetes mellitus (DM).

Setting

The data were obtained from a large-scale prospective cohort study in a single health centre in Beijing.

Participants

A total of 5318 participants aged 18-70 years who underwent health examinations annually with baseline fasting plasma glucose (FPG) ranging from 3.9 to 5.5 mmol/L, without a history of either diabetes or concomitant chronic diseases, were enrolled in this 6-year observational study.

Primary outcome measures

A logistic

SUBMITTER: Li S 

PROVIDER: S-EPMC6059285 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature