Defining acute flares in knee osteoarthritis: a systematic review.

ABSTRACT:

Objective

To identify and critically synthesise definitions of acute flares in knee osteoarthritis (OA) reported in the medical literature.

Design

Systematic review and narrative synthesis. We searched Medline, EMBASE, Web of science and six other electronic databases (inception to July 2017) for original articles and conference abstracts reporting a definition of acute flare (or synonym) in humans with knee OA. There were no restrictions by language or study design (apart from iatrogenic-induced flare-ups, eg, injection-induced). Data extraction comprised: definition, pain scale used, flare duration or withdrawal period, associated symptoms, definition rationale, terminology (eg, exacerbation or flare), baseline OA severity, age, gender, sample size and study design.

Res

SUBMITTER: Parry EL 

PROVIDER: S-EPMC6059300 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature