Maternal lead exposure and premature rupture of membranes: a birth cohort study in China.

ABSTRACT:

Objectives

Maternal exposure to lead (Pb) has been suggested to correlate with adverse birth outcomes, but evidence supporting an association between Pb exposure and premature rupture of membranes (PROM) is limited. The aim of our study was to investigate whether maternal Pb exposure was associated with PROM and preterm PROM.

Design

Cross-sectional cohort study.

Study population

The present study involved 7290 pregnant women from the Healthy Baby Cohort in Wuhan, China, during 2012-2014.

Main outcome measures

PROM was defined as spontaneous rupture of amniotic membranes before the onset of labour and was determined with a pH ≥6.5 for vaginal fluid. Maternal urinary Pb level was adjusted by creatinine concentration, and its relationship with PROM was analysed by

SUBMITTER: Huang S 

PROVIDER: S-EPMC6059302 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature