Reducing the anticholinergic and sedative load in older patients on polypharmacy by pharmacist-led medication review: a randomised controlled trial.

ABSTRACT:

Objective

To evaluate if a pharmacist-led medication review is effective at reducing the anticholinergic/sedative load, as measured by the Drug Burden Index (DBI).

Design

Randomised controlled single blind trial.

Setting

15 community pharmacies in the Northern Netherlands.

Participants

157 community-dwelling patients aged ≥65 years who used ≥5 medicines for ≥3 months, including at least one psycholeptic/psychoanaleptic medication and who had a DBI≥1.

Intervention

A medication review by the community pharmacist in collaboration with the patient's general practitioner and patient.

Primary and secondary outcomes measures

The primary outcome was the proportion of patients whose DBI decreased by at least 0.5. Secondary outcomes were the presence of ant

SUBMITTER: van der Meer HG 

PROVIDER: S-EPMC6059312 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature