Different mechanisms activated by mild versus strong loading in rat Achilles tendon healing.

ABSTRACT:

Background

Mechanical loading stimulates Achilles tendon healing. However, various degrees of loading appear to have different effects on the mechanical properties of the healing tendon, and strong loading might create microdamage in the tissue. This suggests that different mechanisms might be activated depending on the magnitude of loading. The aim of this study was to investigate these mechanisms further.

Methods

Female rats had their right Achilles tendon cut transversely and divided into three groups: 1) unloading (calf muscle paralysis by Botox injections, combined with joint fixation by a steel-orthosis), 2) mild loading (Botox only), 3) strong loading (free cage activity). Gene expression was analyzed by PCR, 5 days post-injury, and mechanical testing 8 days post-inju

SUBMITTER: Hammerman M 

PROVIDER: S-EPMC6059492 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature