Epidemiological significance of dengue virus genetic variation in mosquito infection dynamics.

ABSTRACT: The kinetics of arthropod-borne virus (arbovirus) transmission by their vectors have long been recognized as a powerful determinant of arbovirus epidemiology. The time interval between virus acquisition and transmission by the vector, termed extrinsic incubation period (EIP), combines with vector mortality rate and vector competence to determine the proportion of infected vectors that eventually become infectious. However, the dynamic nature of this process, and the amount of natural variation in transmission kinetics among arbovirus strains, are poorly documented empirically and are rarely considered in epidemiological models. Here, we combine newly generated empirical measurements in vivo and outbreak simulations in silico to assess the epidemiological significance of genetic variation i

SUBMITTER: Fontaine A 

PROVIDER: S-EPMC6059494 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature