Serum proteomic analysis of the anti‑arthritic effects of sinomenine on rats with collagen‑induced arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease, which is characterized by inflammatory synovitis, and the subsequent destruction of articular cartilage and bone. Sinomenine is a traditional Chinese medicine, which has been employed as a clinical treatment for RA for several years in China. The present study investigated the anti‑arthritic effects of sinomenine on Sprague‑Dawley rats with collagen‑induced arthritis (CIA). The differentially expressed proteins in serum were measured by proteomic analysis in order to generate a differentially expressed protein network. A total of 320 differentially expressed proteins were detected in the drug‑treated group compared with in the control group. In the sinomenine‑treated group, 79 differentially expressed proteins were detected compared with

SUBMITTER: Qian X 

PROVIDER: S-EPMC6059692 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature