Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules.

ABSTRACT: High-throughput small-molecule assays play essential roles in biomedical diagnosis, drug discovery, environmental analysis, and physiological function research. Nanoplasmonics holds a great potential for the label-free detection of small molecules at extremely low concentrations. Here, we report the development of nanoplasmonic paper (NP-paper) for the rapid separation and ultrasensitive detection of mixed small molecules. NP-paper employs nanogap-rich silver nanoislands on cellulose fibers, which were simply fabricated at the wafer level by using low-temperature solid-state dewetting of a thin silver film. The nanoplasmonic detection allows for the scalable quantification and identification of small molecules over broad concentration ranges. Moreover, the combination of chromatographic se

SUBMITTER: Jung H 

PROVIDER: S-EPMC6059847 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature