Metformin and JQ1 synergistically inhibit obesity-activated thyroid cancer.

ABSTRACT: Compelling epidemiological evidence shows a strong positive correlation of obesity with thyroid cancer. In vivo studies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model of thyroid cancer (Thrb^PV/PVPten^+/- mice). The Thrb^PV/PVPten^+/- mouse expresses a dominantly negative thyroid hormone receptor β (denoted as PV) and a deletion of one single allele of the Pten gene. The Thrb^PV/PVPten^+/- mouse spontaneously develops follicular thyroid cancer, which allows

SUBMITTER: Park S 

PROVIDER: S-EPMC6059993 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature