Local Glioma Cells Are Associated with Vascular Dysregulation.

ABSTRACT:

Background and purpose

Malignant glioma is a highly infiltrative malignancy that causes variable disruptions to the structure and function of the cerebrovasculature. While many of these structural disruptions have known correlative histopathologic alterations, the mechanisms underlying vascular dysfunction identified by resting-state blood oxygen level-dependent imaging are not yet known. The purpose of this study was to characterize the alterations that correlate with a blood oxygen level-dependent biomarker of vascular dysregulation.

Materials and methods

Thirty-two stereotactically localized biopsies were obtained from contrast-enhancing (n = 16) and nonenhancing (n = 16) regions during open surgical resection of malignant glioma in 17 patients. Preoperative

SUBMITTER: Bowden SG 

PROVIDER: S-EPMC6060022 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature