Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager.

ABSTRACT: Nanophotonics, and more specifically plasmonics, provides a rich toolbox for biomolecular sensing, since the engineered metasurfaces can enhance light-matter interactions to unprecedented levels. So far, biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes. However, the phase response of the plasmonic resonances have rarely been exploited, mainly because this requires a more sophisticated optical arrangement. Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics. It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical pa

SUBMITTER: Yesilkoy F 

PROVIDER: S-EPMC6060062 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature