Novel 3D Structure Based Model for Activity Prediction and Design of Antimicrobial Peptides.

ABSTRACT: The emergence and worldwide spread of multi-drug resistant bacteria makes an urgent challenge for the development of novel antibacterial agents. A perspective weapon to fight against severe infections caused by drug-resistant microorganisms is antimicrobial peptides (AMPs). AMPs are a diverse class of naturally occurring molecules that are produced as a first line of defense by all multi-cellular organisms. Limited by the number of experimental determinate 3D structure, most of the prediction or classification methods of AMPs were based on 2D descriptors, including sequence, amino acid composition, peptide net charge, hydrophobicity, amphiphilic, etc. Due to the rapid development of structural simulation methods, predicted models of proteins (or peptides) have been successfully applied in

SUBMITTER: Liu S 

PROVIDER: S-EPMC6060096 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature