Dynamic multistimuli-responsive reversible chiral transformation in supramolecular helices.

ABSTRACT: The design of new chiral chromophores that allow tunable assembly of higher order helical structures by using natural stimuli offers promising avenue in understanding various biological processes. In particular, access to dynamic multistimuli-responsive systems can provide real-time monitoring of chiral transformation in chemical and biological systems. We report on the synthesis of naphthalenediimide appended L-glutamate (NDI-L-Glu) that self-assembles into chiral supramolecular structures under physiological conditions. Specifically, NDI-L-Glu shows a mixture of left- and right-handed helices under physiological conditions, and any deviation from the ambient biochemical environment has a remarkable influence on the chirality of these structures. For instance, acidic environments shift th

SUBMITTER: Goskulwad S 

PROVIDER: S-EPMC6060148 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature