[¹⁸F]Fluciclovine PET discrimination between high- and low-grade gliomas.

ABSTRACT:

Background

The ability to accurately and non-invasively distinguish high-grade glioma from low-grade glioma remains a challenge despite advances in molecular and magnetic resonance imaging. We investigated the ability of fluciclovine (¹⁸F) PET as a means to identify and distinguish these lesions in patients with known gliomas and to correlate uptake with Ki-67.

Results

Sixteen patients with a total of 18 newly diagnosed low-grade gliomas (n = 6) and high grade gliomas (n = 12) underwent fluciclovine PET imaging after histopathologic assessment. Fluciclovine PET analysis comprised tumor SUV_max and SUV_mean, as well as metabolic tumor thresholds (1.3*, 1.6*, 1.9*) to normal brain background (TB_max, and TB_mean). Comparison w

SUBMITTER: Parent EE 

PROVIDER: S-EPMC6060188 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature