Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution.

ABSTRACT: Calorie restriction (CR) without malnutrition increases life span and health span in multiple model organisms. In non-human and human primates, CR causes changes that protect against several age-related pathologies, reduces inflammation, and preserves or improves cell-mediated immunity. However, CR has also been shown to exhibit adverse effects on certain organs and systems, including the immune system, and to impact genetically different organisms of the same species differentially. Alternately, short periods of fasting followed by refeeding may result in the proliferation of bone marrow stem cells, suggesting a potential rejuvenation effect that could impact the hematopoietic compartment. However, the global consequences of CR followed by refeeding on the immune system have not been care

SUBMITTER: Contreras NA 

PROVIDER: S-EPMC6060198 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature