Responses of the Human Gut Escherichia coli Population to Pathogen and Antibiotic Disturbances.

ABSTRACT: Studies of Escherichia coli in the human gastrointestinal tract have focused on pathogens, such as diarrhea-causing enterotoxigenic E. coli (ETEC), while overlooking the resident, nonpathogenic E. coli community. Relatively few genomes of nonpathogenic E. coli strains are available for comparative genomic analysis, and the ecology of these strains is poorly understood. This study examined the diversity and dynamics of resident human gastrointestinal E. coli communities in the face of the ecological challenges presented by pathogen (ETEC) challenge, as well as of antibiotic treatment. Whole-genome sequences obtained from E. coli isolates from before, during, and after ETEC challenge were used in phylogenomic and comparative genomic analyses to examine the diversity of the resident E. coli c

SUBMITTER: Richter TKS 

PROVIDER: S-EPMC6060285 | biostudies-literature | 2018 Jul-Aug

REPOSITORIES: biostudies-literature