Effects of immunosuppressive agents on the hemostatic system in normal dogs.

ABSTRACT:

Background

In dogs, the effects of immunosuppressive medications on hemostasis are not well known.

Hypothesis/objectives

The objective was to determine the effects of immunosuppressive medications on primary and secondary hemostasis. Our hypothesis was that cyclosporine and prednisone would increase markers of hypercoagulability and thromboxane synthesis, while azathioprine, mycophenolate mofetil, and leflunomide would have minimal effects on hemostasis.

Animals

Eight healthy dogs.

Methods

A randomized, cross-over study used aggregometry, the PFA-100 platelet function analyzer, viscoelastometry, platelet count, and prothrombin and activated partial thromboplastin times to evaluate hemostasis during the administration of prednisone, azathioprine, cyclosporine, m

SUBMITTER: Thomason JM 

PROVIDER: S-EPMC6060322 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature