Grafting from a Hybrid DNA-Covalent Polymer by the Hybridization Chain Reaction.

ABSTRACT: Nucleic acid-polymer conjugates are an attractive class of materials endowed with tunable and responsive character. Herein, we exploit the dynamic character of nucleic acids in the preparation of hybrid DNA-covalent polymers with extendable grafts by the hybridization chain reaction. Addition of DNA hairpins to an initiator DNA-dextran graft copolymer resulted in the growth of the DNA grafts as evidenced by various characterization techniques over several length scales. Additionally, aggregation of the initiator DNA-graft copolymer before the hybridization chain reaction was observed resulting in the formation of kinetically trapped aggregates several hundreds of nanometers in diameter that could be disrupted by a preheating step at 60 °C prior to extension at room temperature. Materials o

SUBMITTER: Noteborn WEM 

PROVIDER: S-EPMC6060401 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature