Redox-Annulations of Cyclic Amines with 2-(2-Oxoethyl)malonates.

ABSTRACT: Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-(2-oxoethyl)malonates in the presence of catalytic amounts of benzoic acid. These reactions install a fully saturated five-membered ring and provide access to structures closely related to the natural products crispine A and harmicine.

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC6060407 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature