Creating a Structured AOP Knowledgebase via Ontology-Based Annotations.

ABSTRACT:

Introduction

The Adverse Outcome Pathway framework is increasingly used to integrate data generated based on traditional and emerging toxicity testing paradigms. As the number of AOP descriptions has increased, so has the need to define the AOP in computable terms.

Materials and methods

Herein, we present a comprehensive annotation of 172 AOPs housed in the AOP-Wiki as of December 4, 2016 using terms from existing biological ontologies.

Results

AOP Key Events (KEs) were assigned ontology terms using a concept called the Event Component, which consists of a Process, an Object, and an Action term, with each term originating from ontologies and other controlled vocabularies. Annotation of KEs with ontology classes from fourteen ontologies and controlled vocabularies resu

SUBMITTER: Ives C 

PROVIDER: S-EPMC6060416 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature